Where is magnesium found in food




















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FDA does not require food labels to list magnesium content unless magnesium has been added to the food. Magnesium supplements are available in a variety of forms, including magnesium oxide, citrate, and chloride [ 2 , 3 ]. The Supplement Facts panel on a dietary supplement label declares the amount of elemental magnesium in the product, not the weight of the entire magnesium-containing compound.

Absorption of magnesium from different kinds of magnesium supplements varies. Forms of magnesium that dissolve well in liquid are more completely absorbed in the gut than less soluble forms [ 2 , 12 ]. Small studies have found that magnesium in the aspartate, citrate, lactate, and chloride forms is absorbed more completely and is more bioavailable than magnesium oxide and magnesium sulfate [ ]. Magnesium is a primary ingredient in some laxatives [ 18 ].

Although such a dose of magnesium is well above the safe upper level, some of the magnesium is not absorbed because of the medication's laxative effect.

Magnesium is also included in some remedies for heartburn and upset stomach due to acid indigestion [ 18 ]. Dietary surveys of people in the United States consistently show that many people consume less than recommended amounts of magnesium. In a study using data from NHANES — to assess mineral intakes among adults, average intakes of magnesium from food alone were higher among users of dietary supplements mg for men and mg for women, equal to or slightly exceeding their respective EARs than among nonusers mg for men and for women [ 23 ].

When supplements were included, average total intakes of magnesium were mg for men and mg for women, well above EAR levels. No current data on magnesium status in the United States are available. Determining dietary intake of magnesium is the usual proxy for assessing magnesium status. NHANES has not determined serum magnesium levels in its participants since [ 24 ], and magnesium is not evaluated in routine electrolyte testing in hospitals and clinics [ 2 ].

Symptomatic magnesium deficiency due to low dietary intake in otherwise-healthy people is uncommon because the kidneys limit urinary excretion of this mineral [ 3 ]. Early signs of magnesium deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur [ 1 , 2 ].

Severe magnesium deficiency can result in hypocalcemia or hypokalemia low serum calcium or potassium levels, respectively because mineral homeostasis is disrupted [ 2 ].

Magnesium inadequacy can occur when intakes fall below the RDA but are above the amount required to prevent overt deficiency. The following groups are more likely than others to be at risk of magnesium inadequacy because they typically consume insufficient amounts or they have medical conditions or take medications that reduce magnesium absorption from the gut or increase losses from the body.

The chronic diarrhea and fat malabsorption resulting from Crohn's disease, gluten-sensitive enteropathy celiac disease , and regional enteritis can lead to magnesium depletion over time [ 2 ]. Resection or bypass of the small intestine, especially the ileum, typically leads to malabsorption and magnesium loss [ 2 ].

The magnesium loss appears to be secondary to higher concentrations of glucose in the kidney that increase urine output [ 2 ]. Magnesium deficiency is common in people with chronic alcoholism [ 2 ]. In these individuals, poor dietary intake and nutritional status; gastrointestinal problems, including vomiting, diarrhea, and steatorrhea fatty stools resulting from pancreatitis; renal dysfunction with excess excretion of magnesium into the urine; phosphate depletion; vitamin D deficiency; acute alcoholic ketoacidosis; and hyperaldosteronism secondary to liver disease can all contribute to decreased magnesium status [ 2 , 27 ].

Older adults have lower dietary intakes of magnesium than younger adults [ 21 , 28 ]. In addition, magnesium absorption from the gut decreases and renal magnesium excretion increases with age [ 29 ]. Older adults are also more likely to have chronic diseases or take medications that alter magnesium status, which can increase their risk of magnesium depletion [ 1 , 30 ].

Habitually low intakes of magnesium induce changes in biochemical pathways that can increase the risk of illness over time. This section focuses on four diseases and disorders in which magnesium might be involved: hypertension and cardiovascular disease, type 2 diabetes, osteoporosis, and migraine headaches.

Hypertension is a major risk factor for heart disease and stroke. Studies to date, however, have found that magnesium supplementation lowers blood pressure, at best, to only a small extent.

A meta-analysis of 12 clinical trials found that magnesium supplementation for 8—26 weeks in hypertensive participants resulted in only a small reduction 2. The authors of another meta-analysis of 22 studies with 1, normotensive and hypertensive adults concluded that magnesium supplementation for 3—24 weeks decreased systolic blood pressure by 3—4 mmHg and diastolic blood pressure by 2—3 mmHg [ 32 ].

A diet containing more magnesium because of added fruits and vegetables, more low-fat or non-fat dairy products, and less fat overall was shown to lower systolic and diastolic blood pressure by an average of 5. However, this Dietary Approaches to Stop Hypertension DASH diet also increases intakes of other nutrients, such as potassium and calcium, that are associated with reductions in blood pressure, so any independent contribution of magnesium cannot be determined.

Several prospective studies have examined associations between magnesium intakes and heart disease. The Atherosclerosis Risk in Communities study assessed heart disease risk factors and levels of serum magnesium in a cohort of 14, white and African-American men and women aged 45 to 64 years at baseline [ 34 ].

Over an average of 12 years of follow-up, individuals in the highest quartile of the normal physiologic range of serum magnesium at least 0. However, dietary magnesium intakes had no association with risk of sudden cardiac death. Another prospective study tracked 88, female nurses in the United States to determine whether serum magnesium levels measured early in the study and magnesium intakes from food and supplements assessed every 2 to 4 years were associated with sudden cardiac death over 26 years of follow-up [ 35 ].

Another prospective population study of 7, adults aged 20 to 75 years in the Netherlands who did not have cardiovascular disease found that low urinary magnesium excretion levels a marker for low dietary magnesium intake were associated with a higher risk of ischemic heart disease over a median follow-up period of Plasma magnesium concentrations were not associated with risk of ischemic heart disease [ 36 ].

Higher magnesium intakes might reduce the risk of stroke. One limitation of such observational studies, however, is the possibility of confounding with other nutrients or dietary components that could also affect the risk of stroke.

A large, well-designed clinical trial is needed to better understand the contributions of magnesium from food and dietary supplements to heart health and the primary prevention of cardiovascular disease [ 39 ]. Diets with higher amounts of magnesium are associated with a significantly lower risk of diabetes, possibly because of the important role of magnesium in glucose metabolism [ 40 , 41 ].

Hypomagnesemia might worsen insulin resistance, a condition that often precedes diabetes, or it might be a consequence of insulin resistance [ 42 ]. Diabetes leads to increased urinary losses of magnesium, and the subsequent magnesium inadequacy might impair insulin secretion and action, thereby worsening diabetes control [ 3 ]. Most investigations of magnesium intake and risk of type 2 diabetes have been prospective cohort studies. A meta-analysis of prospective cohort studies of the association between magnesium intake and risk of type 2 diabetes included 13 studies with a total of , participants and 24, cases of diabetes [ 44 ].

The mean length of follow-up ranged from 4 to 20 years. Investigators found an inverse association between magnesium intake and risk of type 2 diabetes in a dose-responsive fashion, but this association achieved statistical significance only in overweight body mass index [BMI] 25 or higher but not normal-weight individuals BMI less than Again, a limitation of these observational studies is the possibility of confounding with other dietary components or lifestyle or environmental variables that are correlated with magnesium intake.

Only a few small, short-term clinical trials have examined the potential effects of supplemental magnesium on control of type 2 diabetes and the results are conflicting [ 41 , 45 ].

After 30 days of supplementation, plasma, cellular, and urine magnesium levels increased in participants receiving the larger dose of the supplement, and their glycemic control improved.

The American Diabetes Association states that there is insufficient evidence to support the routine use of magnesium to improve glycemic control in people with diabetes [ 45 ]. It further notes that there is no clear scientific evidence that vitamin and mineral supplementation benefits people with diabetes who do not have underlying nutritional deficiencies. Magnesium is involved in bone formation and influences the activities of osteoblasts and osteoclasts [ 49 ]. Magnesium also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis.

Several population-based studies have found positive associations between magnesium intake and bone mineral density in both men and women [ 50 ]. Other research has found that women with osteoporosis have lower serum magnesium levels than women with osteopenia and those who do not have osteoporosis or osteopenia [ 51 ].

These and other findings indicate that magnesium deficiency might be a risk factor for osteoporosis [ 49 ]. Although limited in number, studies suggest that increasing magnesium intakes from food or supplements might increase bone mineral density in postmenopausal and elderly women [ 1 ]. Diets that provide recommended levels of magnesium enhance bone health, but further research is needed to elucidate the role of magnesium in the prevention and management of osteoporosis.

Magnesium deficiency is related to factors that promote headaches, including neurotransmitter release and vasoconstriction [ 53 ]. People who experience migraine headaches have lower levels of serum and tissue magnesium than those who do not.

However, research on the use of magnesium supplements to prevent or reduce symptoms of migraine headaches is limited. The authors of a review on migraine prophylaxis suggested that taking mg magnesium twice a day, either alone or in combination with medication, can prevent migraines [ 54 ].

In their evidence-based guideline update, the American Academy of Neurology and the American Headache Society concluded that magnesium therapy is "probably effective" for migraine prevention [ 55 ].

Because the typical dose of magnesium used for migraine prevention exceeds the UL, this treatment should be used only under the direction and supervision of a healthcare provider. Too much magnesium from food does not pose a health risk in healthy individuals because the kidneys eliminate excess amounts in the urine [ 29 ]. However, high doses of magnesium from dietary supplements or medications often result in diarrhea that can be accompanied by nausea and abdominal cramping [ 1 ].

Forms of magnesium most commonly reported to cause diarrhea include magnesium carbonate, chloride, gluconate, and oxide [ 12 ]. The diarrhea and laxative effects of magnesium salts are due to the osmotic activity of unabsorbed salts in the intestine and colon and the stimulation of gastric motility [ 56 ]. Learn the benefits of magnesium, how much you really need, which foods are good sources of it and whether you should consider a magnesium supplement.

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